Synapses and Epileptic Disorders
Dec 4th 2022
Experimental data about Synaptotagmin-3 (SYT3) in robust synapses
Thanks to bioRxiv.org, and a Creative Commons License BY-NC-ND 4.0
Please don't forget medRxiv.org and the famous arXiv.org!
Here I present the preprint paper:
Fast resupply of synaptic vesicles requires Synaptotagmin-3.
During sustained neuronal firing, SYT3 speeds vesicle replenishment and increases the size of the readily releasable pool of vesicles. SYT3 also mediates a second form of short-term enhancement called facilitation, under conditions of low vesicle release probability. Models of vesicle trafficking suggest that SYT3 could combat synaptic depression by accelerating vesicle docking at active zones. Our results reveal a critical role for presynaptic SYT3 in maintaining reliable high-frequency synaptic transmission in neural circuits.
By Dennis J. Weingarten, Amita Shrestha, Sarah A. Kissiwaa, Evan Spruston, and Skyler L. Jackman.
During sustained neuronal firing, SYT3 speeds vesicle replenishment and increases the size of the readily releasable pool of vesicles. SYT3 also mediates a second form of short-term enhancement called facilitation, under conditions of low vesicle release probability. Models of vesicle trafficking suggest that SYT3 could combat synaptic depression by accelerating vesicle docking at active zones. Our results reveal a critical role for presynaptic SYT3 in maintaining reliable high-frequency synaptic transmission in neural circuits.
By Dennis J. Weingarten, Amita Shrestha, Sarah A. Kissiwaa, Evan Spruston, and Skyler L. Jackman.
Fast resupply of synaptic vesicles requires Synaptotagmin-3
Dennis J. Weingarten, Amita Shrestha, Sarah A. Kissiwaa, Evan Spruston, Skyler L. Jackman
bioRxiv 2021.09.27.462028; doi: https://doi.org/10.1101/2021.09.27.462028
Below an image of the paper and also fancy image of axodendritic synapses. I don't agree so much with 'knockout studies',
but sometimes yes I agree...
In this case, the great relevance is based on a set of potencial novel targets for antiepileptic drugs.
but sometimes yes I agree...
In this case, the great relevance is based on a set of potencial novel targets for antiepileptic drugs.
(Pixabay Creative Commons free image)
In october 2022, this article was accepted in the journal Nature:
Weingarten, D.J., Shrestha, A., Juda-Nelson, K. et al. Fast resupply of synaptic vesicles requires synaptotagmin-3. Nature 611, 320–325 (2022).
https://doi.org/10.1038/s41586-022-05337-1