P300Study Phase 1

P300Study: A Biomarker-Based Approach to ADHD Treatment Response

This document summarizes the P300Study, presented at the 10th World Congress on ADHD (Prague, May 2025).
The study explores the potential of visual ERP (vERP) features, particularly the P300 wave, as predictive biomarkers for methylphenidate (MPH) response in adults with ADHD.

🎯 Objective
To determine whether specific P300 components—elicited via a three-stimulus visual oddball ERP paradigm, including a deviant stimulus—can support individualized treatment strategies by predicting response to MPH.

🔬 Study Highlights
Phase 1 completed with 40 adult participants, combining clinical and electrophysiological assessments.

EEG recordings followed standardized outpatient protocols, processed using MNE-Python and structured via EEG-BIDS.

📐 Main vERP metrics:

  • Mean amplitude (280–450 ms)
  • Peak latency
  • Area Under the Curve (AUC)

🔎 Preliminary findings: untreated adults with ADHD exhibit reduced P300 amplitude and prolonged latency compared to publicly available normative datasets.

🔄 Ongoing Work (Phase 2) Currently analyzing pre- vs. post-treatment ERP data to assess MPH-induced waveform changes and support longitudinal tracking of cognitive response.

🧠 Clinical Relevance This research supports the development of an EEG-based decision support tool for tailoring ADHD treatment, enhancing precision in identifying likely MPH responders.

🛠 Software Tool: P300Study Custom Python-based platform for:

  • Artifact rejection
  • Metric extraction
  • Waveform visualization
  • Complies with FAIR open science principles and is aligned with reproducibility standards.

📌 References Cited in the Poster

  1. Rubia K. Cognitive neuroscience of attention deficit hyperactivity disorder (ADHD) and its clinical translation. Front Hum Neurosci. 2018;12:100. https://doi.org/10.3389/fnhum.2018.00100

  2. Polich J. Updating P300: An integrative theory of P3a and P3b. Clin Neurophysiol. 2007;118(10):2128–2148. https://doi.org/10.1016/j.clinph.2007.04.019

  3. Huang WJ, Chen WW, Zhang X. The neurophysiology of P300—An integrated review. Eur Rev Med Pharmacol Sci. 2015;19(8):1480–8.

  4. Peisch V, Rutter T, Wilkinson CL, Arnett AB. Sensory processing and P300 event-related potential correlates of stimulant response in children with attention-deficit/hyperactivity disorder: A critical review. Clin Neurophysiol. 2021;132(4):953–966. https://doi.org/10.1016/j.clinph.2021.01.015

  5. Arnett AB, Rutter TM, Stein MA. Neural markers of methylphenidate response in children with attention deficit hyperactivity disorder. Front Behav Neurosci. 2022;16:887622. https://doi.org/10.3389/fnbeh.2022.887622

  6. Luck SJ. The design of ERP experiments. In: An Introduction to the Event-Related Potential Technique. 2nd ed. Cambridge (MA): MIT Press; 2014. p. 119–147.

This document is part of the Supplementary Material for the poster titled "Clinical utility of the P300 wave as a biomarker for methylphenidate response in adult patients with ADHD: First phase report", 10th World Congress on ADHD – Prague, May 2025.

📚 Additional recommended references are available as Supplementary Material: Direct link to References (PDF).

👉Full Supplementary Material for the ADHD 2025 Poster

PMS/pms.


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